Alpha-Toluenesulfonyl Chloride (1939-99-7)

We Are Supplier, Exporter And Contract Manufacturer.Technical Profile Of Alpha-Toluenesulfonyl Chloride, A High-Purity Raw Chemical Material Supplied By Triveni Chemicals For Industrial Manufacturing And Laboratory Synthesis.

Alpha-Toluenesulfonyl chloride (C7H7ClO2S), also known as p-toluenesulfonyl chloride (if para isomer is referred), is an organic sulfonyl chloride compound appearing as a white to light yellow crystalline solid with a pungent, irritating odor. It is moisture sensitive and reacts with water to form toluenesulfonic acid and hydrogen chloride. The compound is stable under dry conditions but is highly reactive toward nucleophiles such as amines and alcohols.
In terms of properties, it acts as a strong sulfonylating and activating agent in organic synthesis. It has a melting point around 6770C and is soluble in organic solvents like benzene, chloroform, and ether but insoluble in water.
In terms of applications, alpha-toluenesulfonyl chloride is widely used in pharmaceutical and fine chemical industries as a key intermediate for producing sulfonamides, sulfonate esters, and protecting groups for alcohols and amines (tosyl derivatives). It is also used in organic synthesis for activating functional groups and in agrochemical manufacturing. Additionally, it plays an important role in research laboratories for multi-step synthesis of complex molecules. Due to its corrosive and reactive nature, it requires careful handling and storage.