About Methyl 6-Methylnicotinate
Methyl 6-Methylnicotinate (CAS No. 5457-87-2) is an ester derivative of 6-methylnicotinic acid, belonging to the pyridine carboxylate family. It is used in the fragrance and cosmetic industry, where it imparts a warm, sweet, and slightly spicy aroma.
Key Applications in Pharmaceutical SynthesisMethyl 6-Methylnicotinate is primarily used as an intermediate in the synthesis of pharmaceuticals, including non-steroidal anti-inflammatory drugs like Etoricoxib. Its unique properties and good solubility facilitate its role in the development of enzyme inhibitors, making it a sought-after compound in research laboratories and industry applications. This versatility highlights its importance in advanced organic synthesis.
Physical and Chemical CharacteristicsAppearing as a white crystalline solid, Methyl 6-Methylnicotinate exhibits a melting point between 34C and 37C. Its moderate solubility in methanol and stable nature contribute to its suitability for storage and handling in laboratory and industrial settings. The compound's molecular structure, with the formula C8H9NO2, supports a range of synthetic transformations.
FAQ's of Methyl 6-Methylnicotinate:
Q: How is Methyl 6-Methylnicotinate typically used in the pharmaceutical industry?
A: This compound serves as a crucial intermediate in the synthesis of various pharmaceuticals, most notably in the production of Etoricoxib (a non-steroidal anti-inflammatory drug) and enzyme inhibitors.
Q: What are the benefits of using Methyl 6-Methylnicotinate in organic synthesis?
A: Its moderate solubility and stability, combined with its crystalline solid form, make it an ideal and reliable intermediate for complex organic transformations and pharmaceutical development.
Q: What is the process of synthesizing pharmaceuticals with Methyl 6-Methylnicotinate?
A: Methyl 6-Methylnicotinate is incorporated as a building block in multi-step synthetic routes for drugs. It reacts with other reagents to form key intermediates or final active pharmaceutical ingredients.
Q: Where is Methyl 6-Methylnicotinate manufactured and supplied?
A: This intermediate is manufactured and supplied by companies based in India, serving pharmaceutical and research markets globally.
Q: When should Methyl 6-Methylnicotinate be considered for use in synthesis?
A: It should be selected when a stable, moderately soluble intermediate is needed for the creation of drugs, especially when targeting compounds like Etoricoxib or enzyme inhibitors.
Q: What is the recommended solvent for dissolving Methyl 6-Methylnicotinate?
A: Methanol is the preferred solvent due to the compound's moderate solubility in this medium, supporting efficient processing during synthesis.