Trimethyl Orthoformate (149-73-5)

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Trimethyl Orthoformate (149-73-5) Specification

CAS No
149-73-5

Appearance
Colorless liquid

Molecular Weight
106.12 g/mol Grams (g)

Physical Form
Liquid

Solubility
Miscible with water

Application
Industrial

Melting Point
-60 C

Usage
Formylation and acetal protection in organic synthesis; intermediate in pharmaceutical and fragrance synthesis.

Structural Formula
C4H10O3

Properties
Trimethyl orthoformate is a vital organic reagent used primarily for the protection of aldehydes and ketones as acetals or ketals. Its ability to act as a dehydrating agent and a source of the formyl group makes it indispensable in the synthesis of pharmaceutical intermediates and heterocyclic compounds.

Purity
98 99%

Refractive Rate
1.37

Molecular Formula
C4H10O3

About Trimethyl Orthoformate (149-73-5)

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Technical profile of Trimethyl Orthoformate, a high-purity raw chemical material supplied by Triveni Chemicals for industrial manufacturing and laboratory synthesis.

Technical Specifications:

CAS Number: 149-73-5

Synonyms: Trimethoxymethane, Methyl Orthoformate

Chemical Formula: C4H10O3

Industrial Uses & Applications:

It Is Widely Used As A Reagent And Intermediate In Organic Synthesis, Particularly In The Manufacture Of Pharmaceuticals, Agrochemicals, And Specialty Chemicals. It Is An Orthoester That Readily Reacts With Alcohols, Amines, And Acids And Is Commonly Used For Acetal Formation And Dehydration Reactions.

Key Applications in Organic Synthesis

Trimethyl Orthoformate is a critical reagent in organic chemistry labs, enabling protection of sensitive carbonyl groups through acetal or ketal formation. Its role as a mild dehydrating agent makes it invaluable in the synthesis of heterocyclic and medicinal compounds. Chemists frequently utilize it for formylation steps in active pharmaceutical ingredient (API) production and in a variety of fragrance intermediates.

Physical and Chemical Properties

This compound is a clear, colorless liquid with a molecular weight of 106.12 g/mol, displaying excellent miscibility with water. Its low melting point and high purity (98-99%) make it suitable for precise chemical applications. The combination of its physical characteristics and reactivity as a reagent underscores its versatility in industrial and laboratory environments.

FAQ's of Trimethyl Orthoformate (149-73-5):

Q: How is Trimethyl Orthoformate typically used in chemical synthesis?

A: Trimethyl Orthoformate is mainly used for the protection of aldehydes and ketones by converting them into stable acetals or ketals. It is also employed for formylation reactions, acting as a formyl group donor in the creation of complex organic molecules, especially in the pharmaceutical and fragrance industries.

Q: What is the process for using Trimethyl Orthoformate as a protecting agent?

A: To use Trimethyl Orthoformate as a protecting agent, it is typically mixed with the carbonyl compound and an acid catalyst under controlled conditions. This leads to the formation of acetals or ketals, protecting the carbonyl group from undesired side reactions during subsequent synthetic steps.

Q: When should Trimethyl Orthoformate be applied in synthesis schemes?

A: Trimethyl Orthoformate should be used when there is a need to temporarily protect carbonyl groups during multi-step organic syntheses. It is particularly useful before reactions that might otherwise interact unfavorably with unprotected aldehydes or ketones.

Q: Where is Trimethyl Orthoformate supplied and manufactured?

A: Trimethyl Orthoformate is manufactured and supplied in India by specialized chemical manufacturers focused on industrial and laboratory-scale reagents. It is distributed both domestically and internationally, supporting global supply chains.

Q: What benefits does Trimethyl Orthoformate offer for industrial applications?

A: This compound enables efficient, high-yield transformations in organic processes. Its excellent solubility and reactivity help streamline the protection and modification steps in pharmaceuticals and fragrances, reducing risks of side reactions and improving overall product quality.

Q: Why is Trimethyl Orthoformate preferred for acetal protection over other reagents?

A: Trimethyl Orthoformate is preferred due to its mild yet effective dehydrating ability, high purity, and predictable reactivity. This makes it suitable for sensitive applications and ensures minimal by-product formation during protection processes.

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